Extracellular Vesicle Protein Panel Enables Early Lung Cancer Detection in a Large Clinical Cohort.

ABSTRACT: The early detection and diagnosis of lung cancer through extracellular vesicle (EV)-based liquid biopsy show substantial promise for enhancing clinical outcomes. Nonetheless, there is a scarcity of large-scale clinical investigations validating EV-based liquid biopsy. To evaluate the EV membrane protein panel as a diagnostic tool for early-stage cancer detection and validate its efficacy and clinical applicability, a cohort comprised of 302 individuals without cancer and 645 with lung cancer was recruited. Participants were randomly divided into training and validation cohorts at a 1:1 ratio while maintaining the proportion of different subtypes. A diagnostic panel (EV early lung cancer membrane protein 5, EV^ELC-M5) consisting of five EV membrane proteins (CD81, PDL1, GLIPR1, LB

SUBMITTER: Han L 

PROVIDER: S-EPMC12326191 | biostudies-literature | 2025 Aug

REPOSITORIES: biostudies-literature