Mouse Tumor Tissue-Derived Extracellular Vesicles Induce Angiogenesis Through VEGF Production From Macrophages.

ABSTRACT: Extracellular vesicles (EVs) are nano-sized, spherical, and lipid bilayered particles secreted by most types of cells. Tumor microenvironment is a complex system and highly regulated by dynamic interaction of cancer cells with stromal cells, such as immune cells and endothelial cells. Angiogenesis, a process of new capillary formation from pre-existing vasculatures, plays a critical role in tumorigenesis and cancer progression by providing oxygen and nutrients to proliferating cancer cells. Since EVs have emerged as important mediators of intercellular communication in pathophysiological circumstances, several studies have reported pro-angiogenic activities of EVs derived from in vitro cultured cancer cells and other cells. However, the angiogenic role of EVs directly isolated from in vivo

SUBMITTER: Yoon YJ 

PROVIDER: S-EPMC12326192 | biostudies-literature | 2025 Aug

REPOSITORIES: biostudies-literature