8-Prenylnaringenin suppresses obesity in high-fat diet-fed C57BL/6J mice via adiponectin secretion.

ABSTRACT: 8-Prenylnaringenin (8-PN) is a prenylflavonoid found in hops (Humulus lupulus L.). It has several beneficial functions, which include the inhibition of bone loss and muscle atrophy. 8-PN is a metabolite of xanthohumol, which can prevent obesity in mice; however, the effect of 8-PN on obesity is still unknown. In the present study, we found that 8-PN prevented obesity in high-fat diet-fed mice. When C57BL6/J male mice were fed 8-PN at 0.0005% or 0.005% with a high-fat diet for 8 weeks, body weight gain, fat accumulation in adipose tissue, and fatty liver induced by the high-fat diet were prevented. In mice fed a high-fat diet and 8-PN, adenosine monophosphate-activated protein kinase (AMPK) was activated in visceral adipose tissue, which was accompanied by decreased expression of a f

SUBMITTER: Okada F 

PROVIDER: S-EPMC12326250 | biostudies-literature | 2025 Jul

REPOSITORIES: biostudies-literature