Incidence, Prevalence, and Stability of Remission in Individuals With Clinical High Risk for Psychosis.

ABSTRACT:

Importance

While remission from clinical high risk (CHR) for psychosis is a favorable outcome, it is not well characterized over time.

Objective

To examine remission incidence, prevalence, and stability, and their association with demographic, clinical, medication, and cognitive variables, comparing 2 commonly used definitions.

Design, setting, and participants

This cohort study examined data from individuals aged 12 to 30 years at CHR in the North American Prodromal Longitudinal Study 3, collected from 9 sites across the US from February 2015 to November 2018. Statistical analyses were conducted between January 2023 and May 2025.

Exposure

CHR status using 2 definitions: (1) a symptoms-only definition based on the positive symptoms from the Scale of Prodromal S

SUBMITTER: Seitz-Holland J 

PROVIDER: S-EPMC12326281 | biostudies-literature | 2025 Aug

REPOSITORIES: biostudies-literature