Caulerpin Delivery via Pluronic-Free Cubosomes: Unlocking the Therapeutic Potential of a Pigment from an Invasive Marine Algae.

ABSTRACT: Pancreatic cancer remains one of the deadliest cancers due to its resistance to conventional therapies, necessitating the development of novel treatment strategies. This study investigates the anticancer potential of caulerpin, a bisindole alkaloid derived from the invasive marine alga Caulerpa cylindracea, encapsulated in biocompatible cubosomes. Caulerpin was sustainably extracted via microwave-assisted methods and formulated into lipid-based bicontinuous cubic liquid crystalline nanoparticles using Pluronic-free surfactants (sodium taurocholate and Span 80), resulting in high encapsulation efficiency and structural stability at physiological temperature (37 °C). The formulation included cubosomes coexisting with L3 sponge nanoparticles and vesicles. In vitro studies on BxP

SUBMITTER: Krautforst K 

PROVIDER: S-EPMC12326354 | biostudies-literature | 2025 Aug

REPOSITORIES: biostudies-literature