Cooperative Lewis Acid/Metal Dual Catalysis for the Selective <i>ortho</i>-Alkylation of Phenols.

ABSTRACT: Alkylated phenols hold significant importance in industrial chemistry, as many pharmaceuticals and polymer additives are based on these scaffolds. However, synthesizing these products in a sustainable way is still challenging because stoichiometric amounts of Lewis acids to promote Friedel-Crafts reactions on benzene and phenol derivatives are often employed, together with drastic and unsafe reaction conditions. In this paper, we present a regioselective process to produce ortho-alkylated phenols, with high atom- and step-economy that minimizes the formation of waste associated with it. The key role is pursued by the dual catalytic system palladium on carbon (Pd/C) and scandium trifluoromethanesulfonate (Sc-(OTf)₃), which together promote the partial hydrogenation of phen

SUBMITTER: Di Erasmo B 

PROVIDER: S-EPMC12326393 | biostudies-literature | 2025 Aug

REPOSITORIES: biostudies-literature