Association of Estimated Glucose Disposal Rate With Risk of Abdominal Aortic Aneurysm: Evidence From a Large-Scale Prospective Cohort Study of the UK Biobank.

ABSTRACT:

Background

Insulin resistance has been recognized as a risk factor in the pathogenesis of various diseases. The estimated glucose disposal rate (eGDR) has been widely validated as a reliable, noninvasive, and cost-effective surrogate measure of insulin resistance. However, the relationship between eGDR and abdominal aortic aneurysm (AAA) has not yet been fully elucidated. This study sought to investigate the association between the eGDR levels and the risk of AAA development.

Methods

This prospective cohort study enrolled participants from the UK Biobank who had complete eGDR measurements and no pre-existing AAA at baseline (2006-2010). Participants were stratified into quartiles according to their eGDR values. The association between eGDR and AAA was assessed using Cox prop

SUBMITTER: Chen Y 

PROVIDER: S-EPMC12326403 | biostudies-literature | 2025 Jul

REPOSITORIES: biostudies-literature