Effect of Interactions Between Endothelial Lipase Gene Polymorphisms and Traditional Cardiovascular Risk Factors on Coronary Heart Disease Susceptibility.

ABSTRACT:

Background

Coronary heart disease (CHD) arises from a complex interplay of genetic and environmental factors. This study examines the influence of endothelial lipase gene polymorphisms (rs2000813 and rs3813082) and their interactions with traditional cardiovascular risk factors on CHD susceptibility.

Methods

This retrospective case-control study enrolled 900 CHD patients and 900 control subjects. We evaluated associations between conventional cardiovascular risk factors and polymorphisms at the rs2000813 and rs3813082 loci in the endothelial lipase gene. Multifactorial analysis was used to assess interactions between traditional risk factors and these polymorphisms. Additionally, we developed a predictive model integrating genetic va

SUBMITTER: He C 

PROVIDER: S-EPMC12326425 | biostudies-literature | 2025 Jul

REPOSITORIES: biostudies-literature