Association of Hemoglobin Glycation Index With All-Cause Mortality, Cardiac Mortality, and Cardiovascular Mortality in the General Population: A Retrospective Cohort Study of NHANES Data.

ABSTRACT:

Background

The hemoglobin glycation index (HGI) presents a discrepancy between observed and predicted glycosylated hemoglobin (HbA1c) and fasting blood glucose values. Meanwhile, compared to the HbA1c values, the HGI provides a more comprehensive reflection of blood glucose variability across populations. However, no studies have examined the association between the HGI and all-cause, cardiac, and cardiovascular mortalities in the general population. Hence, this study aimed to investigate these relationships using data from the National Health and Nutrition Examination Survey (NHANES) database.

Methods

Participants were stratified into four groups based on the HGI quartiles. Weighted multivariable Cox proportional hazards models were used to assess the associations between H

SUBMITTER: Mao Q 

PROVIDER: S-EPMC12326456 | biostudies-literature | 2025 Jul

REPOSITORIES: biostudies-literature