Neuropeptide Y mRNA expression in the aging inferior colliculus of fischer brown norway rats.

ABSTRACT:

Introduction

A major contributor to age-related hearing loss is the decline of GABAergic inhibition, particularly in the inferior colliculus (IC), which is the midbrain hub of the central auditory system. The initial loss of inhibition is thought to be a compensatory mechanism in response to decreased peripheral excitation. However, the downregulation of inhibition in the IC persists with age and leads to functional disruptions and central neural gain. Neuropeptide Y (NPY) is co-expressed by a sub-population of GABAergic IC cells whose age-related changes remain unexplored. We sought to characterize GABAergic cells in the major subdivisions of the IC that express NPY mRNA to determine whether NPY mRNA is altered in aging IC cells.

Methods

We used multiplexed fluorescent i

SUBMITTER: Almassri LS 

PROVIDER: S-EPMC12326481 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature