Multiscale Finite Element Modeling of Left Ventricular Growth in Simulations of Valve Disease.

ABSTRACT: Multiscale models of the cardiovascular system are emerging as effective tools for investigating the mechanisms that drive ventricular growth and remodeling. These models can predict how molecular-level mechanisms impact organ-level structure and function and could provide new insights that help improve patient care. MyoFE is a multiscale computer framework that bridges molecular and organ-level mechanisms in a finite element model of the left ventricle that is coupled with the systemic circulation. In this study, we extend MyoFE to include a growth algorithm, based on volumetric growth theory, to simulate concentric growth (wall thickening/thinning) and eccentric growth (chamber dilation/constriction) in response to valvular diseases. Specifically in our model, concentric growth is contro

SUBMITTER: Sharifi H 

PROVIDER: S-EPMC12326515 | biostudies-literature | 2024 Aug

REPOSITORIES: biostudies-literature