Disentangling the impact of obesity, diet, host factors, and microbiota on small intestinal antimicrobial peptide expression.

ABSTRACT: The small intestinal mucosa has the delicate task of allowing absorption of nutrients and limiting microbial colonization at the mucosal surface through production of antimicrobial peptides and proteins (AMPs). However, while environmental factors, including different diets, have been shown to alter AMP expression, the results from the literature are conflicting on their specific impact. Moreover, the interdependence between diet, AMPs, and metabolic health is largely unexplored. The aim of this study was thus to investigate the effect of obesogenic diets, obesity itself, and other variables, including mouse vendor, microbiota composition, and sex, on intestinal AMP expression. By using different dietary interventions in mice, we here show that prolonged intake of an obesogenic Western-sty

SUBMITTER: Puertolas-Balint F 

PROVIDER: S-EPMC12326570 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature