Neurofilament light chain for prognostication after cardiac arrest-first steps towards validation.

ABSTRACT:

Background

After cardiac arrest, many patients remain comatose, and a substantial proportion do not survive. Neuroprognostication is essential for identifying patients with potential for recovery, and those with severe, irreversible hypoxic-ischemic brain injury. Neurofilament light chain (NfL) is a blood-based marker of neuronal injury that is under evaluation for neuroprognostication. NfL have potential advantages over the currently only guideline recommended blood biomarker for neuroprognostication, neuron-specific enolase, including earlier applicability. However, there is no consensus on optimal NfL cut-off levels. A previous large investigation in OHCA patients, identified NfL thresholds with high specificity for poor outcome, and the purpose of the present investigation is t

SUBMITTER: Meyer MAS 

PROVIDER: S-EPMC12326608 | biostudies-literature | 2025 Aug

REPOSITORIES: biostudies-literature