Epidemiology of hepatitis delta virus (HDV) infection and comparison of clinical characteristics and disease progression among patients with HDV vs. hepatitis B mono-infection: real-world data from a large healthcare insurer-provider in Israel.

ABSTRACT:

Background

Hepatitis delta virus (HDV) infection occurs in patients with underlying hepatitis B virus (HBV) infection and is associated with more rapid liver disease progression. This study aimed to describe the epidemiology of HDV, describe HDV management, and compare disease progression among patients with HDV vs. HBV mono-infection in Israel.

Methods

This retrospective cohort study used anonymized data from Maccabi Healthcare Services. HDV prevalence and incidence were calculated among adults in 2010-2021 (latest decade, PCR test available in the database). HDV management and progression to a more advanced disease state and/or death (composite outcome) were examined in 2005-2021 (maximize follow up, antibody test available in the database). Disease progression post-index

SUBMITTER: Hazzan R 

PROVIDER: S-EPMC12326640 | biostudies-literature | 2025 Aug

REPOSITORIES: biostudies-literature