Harnessing extracellular vesicles from adipose-derived stem cells for the treatment of 4-vinylcyclohexene diepoxide-induced premature ovarian insufficiency.

ABSTRACT:

Background

Premature ovarian insufficiency (POI) is a challenging condition with limited effective treatments. Adipose-derived stem cells (ADSCs) have demonstrated potential in tissue repair, and their extracellular vesicles (ADSC-EVs) show more safety in clinical translation. However, the role and mechanism of ADSC-EVs in the treatment of POI are not yet fully understood. This study aims to investigate the protective effects of ADSC-EVs on rat POI models induced by 4-vinylcyclohexene diepoxide (VCD) and to explore the potential therapeutic mechanisms.

Methods

Rat ADSCs and ADSC-EVs were isolated and characterized. The POI rat model was established via intraperitoneal injection of VCD for 15 consecutive days. ADSCs and ADSC-EVs were injected into the ovaries for treatment. O

SUBMITTER: Li Y 

PROVIDER: S-EPMC12326641 | biostudies-literature | 2025 Aug

REPOSITORIES: biostudies-literature