Repair of infarcted myocardium by skeletal muscle-derived mesenchymal stromal cells delivered by a bioprinted collagen patch.

ABSTRACT: Mesenchymal stromal cells (MSC) are commonly investigated for post-infarction cardiac repair because of their angiogenic, anti-inflammatory and immunomodulatory properties. However, autologous sources (bone marrow and adipose tissue) require substantially invasive harvest procedures while allogeneic MSC from the cord raise the issue of batch to batch variability. This study assessed the effects of another under-investigated cell source: the skeletal muscle whose autologous MSC feature the clinically appealing advantage of being retrievable by a minimally invasive microbiopsy. MSC differentiated from induced pluripotent stem cells (iPSC) were selected as controls as they also look clinically attractive because of their high scalability and high degree of reproducibility. In vitro, muscle-de

SUBMITTER: Guesdon R 

PROVIDER: S-EPMC12326654 | biostudies-literature | 2025 Aug

REPOSITORIES: biostudies-literature