Potential causes and associated conditions with anti-sperm antibody production among infertile males: a systematic literature review.

ABSTRACT: This study systematically reviews the literature to explore the potential causes of anti-sperm antibody (ASA) production among infertile men. A comprehensive search of PubMed was conducted in December 2024, utilizing keywords such as "anti-sperm antibody," "immunologic infertility," and related terms. The search yielded 2215 studies, which were screened by title and abstract, excluding 1857 studies. A total of 358 full-text articles were assessed for eligibility, and finally, 51 studies were included. Twenty-three thousand one hundred eight patients were involved in the included studies; 22,702 patients were infertile, and 406 were fertile controls. Infectious disease were the most commonly investigated causes of ASA production including chlamydia trachomatis infection with 9 studies. Hist

SUBMITTER: Haratian K 

PROVIDER: S-EPMC12326684 | biostudies-literature | 2025 Aug

REPOSITORIES: biostudies-literature