Glucuronolactone improves lung injury caused by PRRSV and DON co-challenge by enhancing the Nrf2-mediated antioxidant capacity in weaning piglets.

ABSTRACT: In the pig industry, both deoxynivalenol (DON) challenge and porcine reproductive and respiratory syndrome virus (PRRSV) infection can negatively impact the growth performance of pigs, thereby impairing the healthy development of the industry. Glucuronolactone (GLU) has been shown to be a potent antioxidant that helps alleviate oxidative stress. Therefore, this study aimed to investigate the effect of GLU on oxidative stress and lung injury induced by co-challenge with PRRSV and DON. Eighteen weaned piglets were randomly divided into three groups: control (CON), DON, and DON + GLU. After DON and/or GLU treatment for two weeks, all pigs were intramuscularly injected with PRRSV and treated with DON and/or GLU for another three weeks. Three weeks post-PRRSV infection, piglets in the DON group

SUBMITTER: Hou J 

PROVIDER: S-EPMC12326727 | biostudies-literature | 2025 Aug

REPOSITORIES: biostudies-literature