FSP1 and CoQ10 have the potential to serve as biomarkers for severe preeclampsia.

ABSTRACT:

Background

Severe preeclampsia is a condition that poses a threat to pregnant women and fetuses, which requires prompt treatment and intervention. The ferroapoptosis suppressor protein 1(FSP1)-ubiquinone10 (CoQ10)-nicotinamide adenine dinucleotide phosphate(NADPH) pathway, a recently identified pathway that inhibits ferroptosis, is parallel to the cystine/glutathione (GSH) /GPX4 pathway. However, its expression in pregnant women with severe preeclampsia has not yet been investigated.

Methods

A total of 198 pregnant women were enrolled in the baseline characterization study, and we measure the levels of chemicals, proteins, and mRNAs associated with the FSP1/CoQ10/NADPH pathway in the placenta, umbilical arterial blood, and maternal blood of pregnant women with severe preecla

SUBMITTER: Li P 

PROVIDER: S-EPMC12326806 | biostudies-literature | 2025 Aug

REPOSITORIES: biostudies-literature