Atrophy of hypothalamic subregions increases migraine risk: cross-sectional study and mendelian randomization analysis.

ABSTRACT:

Background

The hypothalamus is a versatile structure comprising several nuclei that play key roles in regulating various biological processes associated with migraine, including hormone secretion, metabolism, circadian rhythm, and autonomic nervous system functions. However, the involvement of hypothalamic subregions in migraine remains unclear.

Methods

Based on T1-weighted MRI data from 76 migraine patients (23 episodic migraine [EM], 53 chronic migraine [CM]) and 35 healthy controls (HCs), we examined group differences in the volume of five hypothalamic subregions. To clarify causal relationships between migraine and hypothalamic volume, we conducted Mendelian randomization (MR) analyses. Mediation analysis was further performed to assess the role of gut microbiota composi

SUBMITTER: Xiong Z 

PROVIDER: S-EPMC12326839 | biostudies-literature | 2025 Aug

REPOSITORIES: biostudies-literature