Hypoxia-induced genome-wide DNA demethylation by DNMT3A and EMT of cancer cells.

ABSTRACT:

Background

Despite the comprehensive advancement in the field of cancer therapeutics, there remains an urgent need to identify new pathophysiological mechanisms that can be targeted in isolation or in combination with existing therapeutic regimens. The epithelial-to-mesenchymal transitions (EMT) induced by hypoxia, cytokines, and growth factors involves acquisition of invasive and migratory properties by cancer cells. Epigenetic alterations of DNA methylations and/or histone modifications cause substantial transcriptomic reprogramming in cancer cells during EMT and metastasis, which can be therapeutically targeted by a thorough understanding of the mutual interactions among the epigenetic processes. Previously, the mammalian DNA methyltransferases (DNMTs) have been shown to possess

SUBMITTER: Chatterjee B 

PROVIDER: S-EPMC12326847 | biostudies-literature | 2025 Aug

REPOSITORIES: biostudies-literature