Corneal epithelial aberrations: a novel diagnostic tool for keratoconus and forme fruste keratoconus.

ABSTRACT:

Purpose

To assess the ability of corneal epithelial aberrations to discriminate forme fruste keratoconus (FFKC) and keratoconus (KC) from normal eyes.

Methods

This prospective, case-control study enrolled 91 right eyes from 91 normal participants, 87 eyes with FFKC and 148 eyes with KC. Epithelial aberrations for the 6-mm pupil were measured using an anterior segment optical coherence tomography (MS-39, CSO). The epithelial root mean square of higher and lower-order aberrations (total RMS), root mean square of higher-order aberrations (HOAs RMS, from the 3rd to the 7th Zernike polynomials), coma, trefoil, spherical aberration, and secondary astigmatism were recorded. Stepwise logistic regression was utilized to develop the epithelial aberrations index (EAI) for obtaining the

SUBMITTER: Ning R 

PROVIDER: S-EPMC12326862 | biostudies-literature | 2025 Aug

REPOSITORIES: biostudies-literature