Compromised PGF2α signaling in the paraventricular hypothalamic nucleus contributes to the central sensitization of the nitroglycerin-induced chronic migraine in male mice.

ABSTRACT: Impaired descending inhibitory controls are now understood to exacerbate central sensitization of chronic migraine, yet the underlying neural and molecular mechanisms remain largely elusive. Herein, a paraventricular hypothalamic nucleus (PVN) ^{oxytocin (OXT)} → trigeminal nucleus caudalis (TNC) ^GABA neural circuit was identified through the application of a rigorous anterograde tracing strategy and RNAscope in situ hybridization techniques, involved in regulating trigeminal nociceptive transmission. In both episodic and chronic migraine mouse models induced by nitroglycerin (NTG) injections, increased activity of the PVN ^OXT → TNC ^GABA circuit was observed. However, the activity of PVN ^OXT neurons decreased in chronic migraine mice when

SUBMITTER: Hu X 

PROVIDER: S-EPMC12326868 | biostudies-literature | 2025 Aug

REPOSITORIES: biostudies-literature