Cardiovascular autonomic dysfunction precedes cardiovascular disease and all-cause mortality: 11-year follow-up in the ADDITION-PRO study.

ABSTRACT:

Aim

We aim to determine the impact of multiday heart rate variability (HRV) on the risk of major adverse cardiovascular events (MACE), heart failure and mortality in people at high risk of diabetes.

Materials and methods

Multiday HRV and mean heart rate (mHR) were measured in 1627 participants from the ADDITION-PRO study between 2009 and 2011. As measurement for HRV, we calculated a proxy for standard deviation of normal heartbeat (SDNN) both weekly, daily and hourly. Data on MACE and all-cause mortality were obtained from Danish patient registers until 2021. We fitted Poisson regression to determine incidence rate ratios (IRR) for MACE (myocardial infarction, stroke and cardiovascular death), heart failure and all-cause mortality.

Results

Mean (SD) age was 66 years (

SUBMITTER: Schaarup JR 

PROVIDER: S-EPMC12326908 | biostudies-literature | 2025 Sep

REPOSITORIES: biostudies-literature