Alterations in the functional MRI-based temporal brain organisation in individuals with obesity.

ABSTRACT:

Aims

Obesity is associated with functional alterations in the brain. Although spatial organisation changes in the brains of individuals with obesity have been widely studied, the temporal dynamics in their brains remain poorly understood. Therefore, in this study, we investigated variations in the intrinsic neural timescale (INT) across different degrees of obesity using resting-state functional and diffusion magnetic resonance imaging data from the enhanced Nathan Kline Institute Rockland Sample database.

Materials and methods

We examined the relationship between the INT and obesity phenotypes using supervised machine learning, controlling for age and sex. To further explore the structure-function characteristics of these regions, we assessed the modular network properties

SUBMITTER: Lee S 

PROVIDER: S-EPMC12326918 | biostudies-literature | 2025 Sep

REPOSITORIES: biostudies-literature