EUCAST olorofim MICs for 3,550 Danish mold and dermatophyte isolates from 2020 to 2023.

ABSTRACT: The dihydroorotate dehydrogenase (DHODH) inhibitor olorofim has potent activity against most molds. Recent reports of in vitro acquired resistance to olorofim and an agrochemical fungicide DHODH inhibitor warrant continuous monitoring of in vitro activity of olorofim. We examined the activity of olorofim against a contemporary, large collection of molds and explored the impact of different dilution schemes used for the preparation of microdilution plates. In total, 3,550 isolates referred to Statens Serum Institut during 2020-2023 were analyzed. Isolates were identified with matrix-assisted laser desorption/ionization time-of-flight mass spectrometry (MALDI-TOF MS) and/or sequencing. MICs of olorofim, amphotericin B, itraconazole, posaconazole, voriconazole, isavuconazole, an

SUBMITTER: Meletiadis J 

PROVIDER: S-EPMC12326962 | biostudies-literature | 2025 Aug

REPOSITORIES: biostudies-literature