Detection of SXT/R391 integrative conjugative elements carrying tigecycline resistance genes in <i>Shewanella</i> spp. isolated from retail seafood.

ABSTRACT: Tigecycline is a last resort antibiotic that is used to treat serious infections; however, some bacteria have developed tigecycline resistance by producing a tigecycline-inactivating enzyme or tigecycline resistance efflux pump, encoded by tet(X) and tmexCD-toprJ genes, respectively. Tons of seafood are consumed annually in China; however, whether seafood harbors tigecycline-resistant bacteria is not known. In this study, we isolated various tigecycline-resistant bacteria from retail seafood; among these, Shewanella was the predominant tigecycline-resistant genus (33/76, 43.4%). Genomic sequencing revealed that two Shewanella strains carried the tet(X4) gene, while one Shewanella chilikensis strain co-harbored tmexCD2-toprJ2 and bla

SUBMITTER: Zhang W 

PROVIDER: S-EPMC12326977 | biostudies-literature | 2025 Aug

REPOSITORIES: biostudies-literature