Antibiotic synergy against <i>Staphylococcus aureus</i>: a systematic review and meta-analysis.

ABSTRACT: Antimicrobial combinations have been extensively evaluated in vitro to identify synergistic combinations for clinical use. Despite the available literature, no studies comprehensively summarize the findings for antimicrobial combinations against Staphylococcus aureus. We performed a systematic review to identify synergistic combinations that may be beneficial for clinical use against S. aureus. The PubMed, Cochrane, and Web of Science databases were queried from inception to February 2024 for studies of in vitro assays evaluating two antimicrobials in combination against isolates of S. aureus. Studies were included if they used common methods to determine synergy including time-kill assays, checkerboard assays, or the combined gradient diffusion method. T

SUBMITTER: Mellett M 

PROVIDER: S-EPMC12326989 | biostudies-literature | 2025 Aug

REPOSITORIES: biostudies-literature