Aztreonam plus ceftazidime-avibactam for post-neurosurgical meningitis due to <i>Stenotrophomonas maltophilia</i>.

ABSTRACT: Clinical evidence is lacking regarding the efficacy of aztreonam-avibactam in severe infections involving Stenotrophomonas maltophilia. We report a case of post-neurosurgical meningitis due to S. maltophilia (minimal inhibitory concentration of aztreonam plus avibactam, 4/4 µg/mL) clinically and microbiologically cured with a combination of aztreonam and ceftazidime-avibactam (2 g and 2 g/500 mg q8h, 3 h simultaneous infusions). Therapeutic drug monitoring showed adequate concentrations of aztreonam and avibactam in the cerebrospinal fluid at each time point over the 14-day treatment duration.

SUBMITTER: Wong-So J 

PROVIDER: S-EPMC12327007 | biostudies-literature | 2025 Aug

REPOSITORIES: biostudies-literature