Distribution of acyclovir in central nervous system compartments: a porcine pharmacokinetic model.

ABSTRACT: Herpes simplex virus (HSV) encephalitis is a severe infection with high mortality and neurological sequelae if untreated. Intravenous acyclovir (ACV) is the standard treatment, but its central nervous system (CNS) penetration is not fully understood. To evaluate the distribution of ACV in various CNS compartments in a porcine pharmacokinetic model, 12 female pigs were divided into two groups: group I receiving a single ACV dose (10 mg/kg) and group II receiving three doses over 24 h. Microdialysis sampled unbound ACV concentrations in cortical and subcortical extracellular fluid (ECF), ventricular cerebrospinal fluid (CSF), and cisternal CSF. The ACV target concentration was defined as peak concentration (fC_max)  > inhibitory concentration 50% (IC₅₀) for HSV-1

SUBMITTER: Mariager T 

PROVIDER: S-EPMC12327012 | biostudies-literature | 2025 Aug

REPOSITORIES: biostudies-literature