Addressing Signal Drift and Screening for Detection of Biomarkers with Carbon Nanotube Transistors.

ABSTRACT: Electrical biosensors, including transistor-based devices (i.e., BioFETs), have the potential to offer versatile biomarker detection in a simple, low-cost, scalable, and point-of-care manner. Semiconducting carbon nanotubes (CNTs) are among the most explored nanomaterial candidates for BioFETs due to their high electrical sensitivity and compatibility with diverse fabrication approaches. However, when operating in solutions at biologically relevant ionic strengths, CNT-based BioFETs suffer from debilitating levels of signal drift and charge screening, which are often unaccounted for or sidestepped (but not addressed) by testing in diluted solutions. In this work, we present an ultrasensitive CNT-based BioFET called the D4-TFT, an immunoassay with an electrical readout, which overcomes char

SUBMITTER: Albarghouthi FM 

PROVIDER: S-EPMC12327215 | biostudies-literature | 2024 Feb

REPOSITORIES: biostudies-literature