Contrast-enhanced computed tomography for ex vivo assessment of human kidneys: A proof-of-concept study.

ABSTRACT:

Background

Ex vivo perfusion of transplant-declined human organs has emerged as a promising platform to study the response of an organ to novel therapeutic strategies. However, to fully realize the capability of this platform for performing translational research in human organ pathophysiology, there is a need for robust assays to assess organ function and disease. State-of-the-art research methods rely on analyses of biopsies taken during perfusion, which both damages the organ and only provides localized information. Developing non-invasive, whole organ methods of assessment is critical to the further development of this research platform.

Methods

We use ex vivo cold infusion scanning (EXCIS) with contrast-enhanced computed tomography (CT) to quantify perfusion in kidneys

SUBMITTER: Feizi A 

PROVIDER: S-EPMC12327401 | biostudies-literature | 2024 Dec

REPOSITORIES: biostudies-literature