Hyaluronan synthesis inhibition normalizes ethanol-enhanced hepatic stellate cell activation.

ABSTRACT:

Background

Chronic ethanol overconsumption promotes alcohol-associated liver disease (ALD), characterized by hepatocyte injury, inflammation, hepatic stellate cell (HSC) activation, and fibrosis. Hyaluronan (HA) concentration is greater in livers and blood from advanced ALD patients than patients with advanced non-ALD. In the liver, HSCs are the major HA producers. The relationship between ethanol, HA, and HSC activation is incompletely understood. Thus, here, we tested the hypothesis that ethanol enhances HSC activation in a HA-dependent manner.

Methods

Liver tissue microarrays (TMAs) containing steatotic livers from donors with or without a history of alcohol consumption were used to measure HA and collagen content. Mice were fed a moderate (2%, v/v) ethanol-containing die

SUBMITTER: Kotulkar M 

PROVIDER: S-EPMC12327409 | biostudies-literature | 2023 Aug

REPOSITORIES: biostudies-literature