YAP regulates transcriptional programs for layer-specific periosteal expansion during fracture repair.

ABSTRACT: Bone fracture repair initiates by periosteal expansion. The periosteum is a bilayered tissue composed of inner cambium and outer fibrous layers. Typically quiescent, periosteal progenitor cells proliferate upon fracture; however, the underlying transcriptional mechanisms remain unclear. Here, we show that deletion of the transcriptional regulators, yes-associated protein (YAP) and transcriptional coactivator with PDZ binding motif (TAZ), from Osterix-expressing cells, which reside in the cambium, impairs periosteal expansion. YAP activation increases chromatin accessibility, preferentially at TEA domain transcription factor (TEAD) binding sites, and regulates both cell-intrinsic and cell-extrinsic cellular functions. We identify bone morphogenetic protein 4 (Bmp4) as a YAP-TEAD targ

SUBMITTER: Nijsure MP 

PROVIDER: S-EPMC12327455 | biostudies-literature | 2025 Aug

REPOSITORIES: biostudies-literature