Ash2l, an obligatory component of H3K4 methylation complexes, regulates neural crest development.

ABSTRACT: The vertebrate nervous system develops from embryonic neural plate and neural crest. Although genetic mechanisms governing vertebrate neural development have been investigated in depth, epigenetic regulation of this process remains less understood. Redundancy of epigenetic factors and early lethality of animals deficient in critical epigenetic components pose major challenges in characterization of epigenetic factors in vertebrate neural development. In this study, we use the amphibian model Xenopus laevis to investigate the roles of non-redundant, obligatory components of all histone H3K4 activating methylation complexes (COMPASS, also known as SET1/MLL complexes) in early neural development. The two genes that we focus on, Ash2l and Dpy30, regulate mesendodermal differentiation in mouse

SUBMITTER: Mohammadparast S 

PROVIDER: S-EPMC12327496 | biostudies-literature | 2022 Dec

REPOSITORIES: biostudies-literature