Behavioral inflexibility through overtraining is mediated by reduced mGluR1/5 signaling capacity in the dorsolateral striatum.

ABSTRACT: The control of instrumental actions engages distinct behavioral strategies whose contributions are regulated with experience. Instrumental performance, which depends on the causal relationship between actions and their outcomes (A-O), relies on flexible, goal-directed control of behavior. Actions can become less sensitive to changes in action-outcome (A-O) contingencies with repetition, resulting in more inflexible, habitual behaviors. The loss of flexibility with repetition requires plasticity at corticostriatal circuits. However, the underlying molecular mechanisms are not yet established, and how these mechanisms specifically relate to the inability to adapt to new contingencies is unknown. In mice, we find that inflexible behavioral performance following overtraining of an appetitive i

SUBMITTER: Paget-Blanc V 

PROVIDER: S-EPMC12327642 | biostudies-literature | 2025 Jul

REPOSITORIES: biostudies-literature