Multi-scale computational modeling towards efficacy in radiopharmaceutical therapies while minimizing side effects: Modeling of amino acid infusion.

ABSTRACT: Amino acid infusion (AAI) is a technique used in radiopharmaceutical therapy (RPT) to reduce toxicity in kidney and increase clearance rate of radiopharmaceuticals from body. In this study our aim is to evaluate its effect in personalized RPT considering kidney and salivary glands as dose limiting organs using a multiscale modeling framework. We developed a Physiologically-Based Pharmacokinetic (PBPK) model consisting of 19 compartments, personalized it for four prostate cancer patients using data derived from gamma camera imaging. This model was used to investigate the influence of AAI on the absorbed dose to tumors and organs at risk. We then computed the maximum safe injected activity based on the PBPK model. To address the effects of interstitial fluid pressure (IFP) and tumor heteroge

SUBMITTER: Golzaryan A 

PROVIDER: S-EPMC12327665 | biostudies-literature | 2025 Jul

REPOSITORIES: biostudies-literature