Trauma-predictive brain network connectivity adaptively responds to mild acute stress.

ABSTRACT: Past traumatic experiences shape neural responses to future stress, but the mechanisms underlying this dynamic interaction remain unclear. Here, we assessed how trauma-related brain networks respond to current acute stress in real time. Using a machine learning approach, we trained and tested brain functional connectivity networks to predict past trauma exposure in a community sample of adults (N = 170). We then evaluated the response of these trauma-predictive brain networks to an acute emotional and physiological stressor in a subsample of participants (N = 92) and to a pharmacological manipulation (hydrocortisone) in an independent crossover study (N = 27). We found that connectome-based predictive modeling successfully predicted past trauma exposure. The network as

SUBMITTER: Hardi FA 

PROVIDER: S-EPMC12327799 | biostudies-literature | 2025 Aug

REPOSITORIES: biostudies-literature