Microbes and Glomerular Filtration Rate in Health and CKD in Mice.

ABSTRACT:

Background

Microbes are implicated in a variety of host physiological and pathophysiological processes. In this study, we tested the hypothesis that microbes modulate glomerular filtration rate (GFR) in health and chronic kidney disease.

Methods

To uncover the effect of gut microbiota on kidney function in health and in a chronic kidney disease (CKD) model, we examined GFR, plasma creatinine, and kidney histology in mice when gut microbes were manipulated.

Results

In healthy mice, GFR was significantly increased when gut microbiota were either suppressed (oral antibiotics) or absent (germ-free). In mice challenged with adenine diet to induce CKD with impaired GFR, suppressing gut microbes with antibiotics also increased GFR. In females on an adenine diet, antibiotics

SUBMITTER: Xu J 

PROVIDER: S-EPMC12327800 | biostudies-literature | 2025 Jul

REPOSITORIES: biostudies-literature