Comparative analysis of apixaban vs. enoxaparin for thromboprophylaxis after radical cystectomy A single-center, observational, before-after study.

ABSTRACT:

Introduction

Radical cystectomy (RC) is the standard treatment for muscle-invasive and select high-risk non-muscle-invasive bladder cancer. Venous thromboembolism (VTE) is a common and preventable postoperative complication. Extended thromboprophylaxis with low-molecular-weight heparin, such as enoxaparin, is recommended, but direct-acting oral anticoagulants like apixaban are a possible alternative. This study evaluated the safety and efficacy of apixaban compared to enoxaparin for extended postoperative thromboprophylaxis following RC.

Methods

A single-center, observational, before-after study of RCs performed between October 2021 and August 2024 was conducted. Patients receiving 28 days of post-discharge thromboprophylaxis with either enoxaparin or apixaban were included.

SUBMITTER: Macklin CS 

PROVIDER: S-EPMC12327890 | biostudies-literature | 2025 Aug

REPOSITORIES: biostudies-literature