New Discorhabdin D Analogues from <i>Latrunculia</i> spp. Sponges.

ABSTRACT: Chemical profiles of Latrunculia kaakaariki and Latrunculia brevis were investigated, resulting in the isolation of five new discorhabdin D derivatives 1 and 3-6. Their planar structures were solved by combination of NMR and HR-MS, while J-based configurational analysis, computational techniques, and semisynthetic methods were used for the establishment of their absolute configurations. New natural products were tested for their growth inhibitory activity against the NCI-60 human tumor cell line panel, and two compounds 5 and 6 showed low micromolar potency.

SUBMITTER: Orfanoudaki M 

PROVIDER: S-EPMC12327899 | biostudies-literature | 2024 Nov

REPOSITORIES: biostudies-literature