Gestational exposures to mixtures of multiple chemical classes and autism spectrum disorder in the MARBLES study.

ABSTRACT:

Background

Previous epidemiologic studies on gestational chemical exposures and autism spectrum disorder (ASD) often lack analysis of chemical mixtures or are limited to investigating certain chemical classes.

Objective

We examined the impact of multi-class chemical mixtures on ASD risk, using data from the MARBLES (Markers of Autism Risks in Babies-Learning Early Signs) cohort.

Methods

Children were clinically assessed at age 3 and classified as ASD, typical development (TD), or non-TD with other neurodevelopmental concerns. In blood or urine from 105 pregnant mothers, we quantified 42 biomarkers across 5 chemical classes: per- and polyfluoroalkyl substances (PFAS), parabens, phenols, phthalates, and organophosphate esters (OPEs). We only analyzed 30 biomarkers detec

SUBMITTER: Choi JW 

PROVIDER: S-EPMC12328019 | biostudies-literature | 2025 Aug

REPOSITORIES: biostudies-literature