Immunogenic cell death-related genes as prognostic biomarkers and therapeutic insights in uterine corpus endometrial carcinoma: an integrative bioinformatics analysis.

ABSTRACT:

Introduction

Immunogenic cell death (ICD) is the phenomenon in which tumor cells undergo the transition from a non-immunogenic state to an immunogenic state upon their demise as a result of external stimuli. While ICD systems have been widely adopted in oncological research, their specific utilization for Uterine Corpus Endometrial Carcinoma (UCEC) investigations has received comparatively little attention.

Methods

The ICD score was assessed using single-sample gene set enrichment analysis (ssGSEA). Differentially expressed genes (DEGs) were identified from transcriptomic data processed with the "DESeq2" R package. A prognostic model was then developed by integrating these DEGs with clinical variables. The immune landscape was characterized through multiple bioinformatics ap

SUBMITTER: Yi T 

PROVIDER: S-EPMC12328154 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature