A molecular cell atlas of mouse lemur, an emerging model primate.

ABSTRACT: Mouse lemurs are the smallest and fastest reproducing primates, as well as one of the most abundant, and they are emerging as a model organism for primate biology, behaviour, health and conservation. Although much has been learnt about their ecology and phylogeny in Madagascar and their physiology, little is known about their cellular and molecular biology. Here we used droplet-based and plate-based single-cell RNA sequencing to create Tabula Microcebus, a transcriptomic atlas of 226,000 cells from 27 mouse lemur organs opportunistically obtained from four donors clinically and histologically characterized. Using computational cell clustering, integration and expert cell annotation, we define and biologically organize more than 750 lemur molecular cell types and their full gene expression

SUBMITTER: Tabula Microcebus Consortium 

PROVIDER: S-EPMC12328211 | biostudies-literature | 2025 Aug

REPOSITORIES: biostudies-literature