R9AP is a common receptor for EBV infection in epithelial cells and B cells.

ABSTRACT: Epstein-Barr virus (EBV) persistently infects more than 90% of the human population, causing infectious mononucleosis¹, susceptibility to autoimmune diseases² and multiple malignancies of epithelial or B cell-origin³. EBV infects epithelial cells and B cells through interaction between viral glycoproteins and different host receptors⁴, but it has remained unknown whether a common receptor mediates infection of its two major host cell targets. Here, we establish R9AP as a crucial EBV receptor for entry into epithelial and B cells. R9AP silencing or knockout, R9AP-derived peptide and R9AP monoclonal antibody each significantly inhibit, whereas R9AP overexpression promotes, EBV uptake into both cell types. R9AP binds directly to the EBV glycoprotein

SUBMITTER: Li Y 

PROVIDER: S-EPMC12328216 | biostudies-literature | 2025 Aug

REPOSITORIES: biostudies-literature