Case Report: Genetic predisposition to low-dose NSAID-induced liver injury in real-world China.

ABSTRACT: Non-steroidal anti-inflammatory drug (NSAID)-induced liver injury represents approximately 10% of reported drug-induced liver injury (DILI) cases, predominantly through idiosyncratic mechanisms. While epidemiological data are largely derived from Western populations with high NSAID utilization, China exhibits lower use of NSAIDs due to cultural preferences and the widespread use of traditional therapies. During the 2022-2023 Omicron outbreak in China, we observed a surge in DILI cases coinciding with increased NSAID use. This study reports two young male patients who developed severe cholestatic DILI following low-dose ibuprofen intake (400 mg), despite lacking conventional risk factors. Genetic analysis revealed compound heterozygous mutations in ABCB11 (encoding the bile salt expo

SUBMITTER: Lyu Y 

PROVIDER: S-EPMC12328316 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature