MRI-based multiregional radiomics for preoperative prediction of Ki-67 expression in meningiomas: a two-center study.

ABSTRACT:

Background

High expression of Ki-67 in meningioma is significantly associated with higher histological grade and worse prognosis. The non-invasive and dynamic assessment of Ki-67 expression levels in meningiomas is of significant clinical importance and is urgently required. This study aimed to develop a predictive model for the Ki-67 index in meningioma based on preoperative magnetic resonance imaging (MRI).

Methods

This study included 196 patients from one center (internal cohort) and 92 patients from another center (external validation cohort). Meningioma had to have been pathologically confirmed for inclusion. The Ki-67 index was classified as high (Ki-67 ≥ 5%) and low (Ki-67 < 5%). The internal cohort was randomly assigned to training and validation sets at a 7:3 ratio.

SUBMITTER: Luo M 

PROVIDER: S-EPMC12328361 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature