Metabolome-wide associations with short-term exposure to PM_2.5-bound polycyclic aromatic hydrocarbons: a study in older adults.

ABSTRACT:

Background

Emerging evidence links fine particulate matter (PM_2.5) and its polycyclic aromatic hydrocarbon (PAH) components to adverse health outcomes. However, the biological mechanisms driving these associations remain unclear. This study innovatively integrates personal exposure monitoring and untargeted metabolomics in an older adult population to investigate the differential impacts of individual PM_2.5-bound PAHs on metabolic pathways and elucidate their roles in health risks.

Methods

In this study, we enlisted the participation of 112 healthy older adults. We employed personal samplers to monitor the concentrations of pollutants throughout the study period. Furthermore, we conducted an untargeted metabolomic analysis of plasma samples using a liqu

SUBMITTER: Hu H 

PROVIDER: S-EPMC12328383 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature