Global clinical trials on stem cell therapy for autoimmune diseases: trends and future directions.

ABSTRACT:

Background

Autoimmune diseases, such as Crohn's disease (CD) and systemic lupus erythematosus (SLE), lead to progressive multi-organ damage due to immune dysregulation and chronic inflammation. Current therapies lack efficacy and safety, often failing to sustain remission. Stem cell therapy has emerged as a promising approach for immune modulation and tissue repair. This study analyzes clinical trial trends and challenges of stem cell therapy in autoimmune diseases.

Methods

Clinical trial data (2006-2025) were extracted from Trialtrove. Strict inclusion criteria were applied, restricting the analysis to interventional trials while excluding observational studies, non-autoimmune disease trials, and records with incomplete information. Descriptive statistics were used to analy

SUBMITTER: Chen Y 

PROVIDER: S-EPMC12328461 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature