Gut microbiota regulates innate anxiety through neural activity of medial prefrontal cortex in male mice.

ABSTRACT:

Introduction

Innate anxiety, a stable personality trait conceptualized as trait anxiety, represents a fundamental dimension of individual differences in emotional regulation. Clinical evidence and animal studies indicate that elevated innate anxiety significantly increases susceptibility to psychiatric disorders. While the gut microbiota has been increasingly recognized as a critical modulator of neuropsychiatric health, its specific contribution to innate anxiety has yet to be fully elucidated.

Methods

We investigated gut microbiota contributions to innate anxiety in mice using stratified behavioral phenotyping in the elevated plus maze (EPM), antibiotic (ABX)-mediated microbiota depletion, fecal microbiota transplantation (FMT), c-FOS staining, transcriptomic profiling, an

SUBMITTER: Ren J 

PROVIDER: S-EPMC12328517 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature